This Practice Note summarises the law relating to marketing authorisation (MAs) for medicinal products to be placed on the market in the UK following the end of the Brexit transition period (11 pm (GMT) on 31 December 2020, referred to in UK law as ‘IP completion day’). It discusses: • exemptions from the requirement to have an MA (eg ‘specials’, investigational medicinal product (IMPs), early access to medicines scheme (EAMS)) • the different types of MA • the different licensing routes to obtain an MA in the UK, Great Britain (GB), or Northern Ireland (NI) (eg Northern Ireland Medicines and Healthcare products Regulatory Agency (MHRA) Authorised Route (NIMAR), Innovative Licensing and Access Pathway (ILAP), unfettered access, 150-day accelerated national procedure, rolling review, the different routes for reliance on different types of EU authorisations now integrated into the International Recognition Procedure (IRP), Project Orbis and Access Consortium) • while addressing information on the implementation of the Ireland/Northern Ireland Protocol as amended under the Windsor Framework, and • the different offences and penalties if the provisions