The Member State Coordination Group on Health Technology Assessment (HTA CG) has adopted general principles on the use of artificial intelligence (AI) in the preparation of dossiers for Joint Clinical Assessments (JCAs). The guidance sets out expectations for Health Technology Developers (HTDs) to ensure scientific quality, transparency and compliance with Regulation (EU) 2021/2282. HTDs remain fully responsible for the content, methods and findings of their dossiers, including the accuracy and validity of AI-generated outputs. Human oversight must be maintained throughout the process, and no stage should be fully automated without human accountability. AI use must comply with copyright, data protection and the EU AI Act, and must not affect compliance with HTA methodological guidance. Where AI is used, HTDs should document all AI-assisted activities and identify AI-generated or AI-informed outputs, although AI used only for spelling and grammar correction does not need to be disclosed. Dossiers should also report the AI tool's name, version, date, developer and intended purpose. Records of prompts should be retained and made available on request during the JCA process.