This Practice Note is intended to be used to track the progress of European Health Data Space (EHDS) updates, including legislative developments, industry reactions (eg European Federation of Pharmaceutical Industries and Associations (EFPIA), MedTech Europe), key regulatory guidance and initiatives, and consultations. Overview of the European Health Data Space Regulation The EHDS is the first sector-specific initiative under the broader European strategy for data, which includes Regulation (EU) 2023/2854, the EU Data Act, and Regulation (EU) 2022/868, the EU Data Governance Act (EU DGA). It introduces a harmonised legal framework to govern the access, exchange, and use of electronic health data (EHD) across the EU. On 3 May 2022, the European Commission introduced the Proposal for a Regulation on the EHDS and on 25 March 2025, Regulation (EU) 2025/327 on the European Health Data Space and amending Directive 2011/24/EU and Regulation (EU) 2024/2847 (the EHDS Regulation) entered into force, marking the beginning of the transition period. Its provisions will apply in stages, with key dates detailed below (see: Legislative developments and industry reactions). Objective