The European Chemicals Agency (ECHA) has published an updated Key Areas of Regulatory Challenge report, identifying three new regulatory science research priorities. These include: (1) environmental impacts of chemicals at ecosystem level, to strengthen links between risk assessment, biodiversity protection and socio-economic decision-making; (2) mobility of persistent substances, including the need for improved methods and models to identify contaminants that can spread widely in water systems and (3) resistance to biocides, requiring harmonised methods to assess risks and maintain the effectiveness of treatments. ECHA calls for targeted research to address gaps in environmental risk assessment and support evidence-based decisions on EU chemical safety. The Executive Director of ECHA, Dr Sharon McGuinness, also announced the establishment of a new Science Council to align scientific efforts with regulatory needs.