This Practice Note forms part of the wider suite of content on sewerage and drainage and focuses on the regulatory framework governing the sewerage system as a whole in England and Wales. It sits alongside related materials addressing sewerage undertakers’ core duties and powers, the maintenance and protection of sewers, discharges from sewers and drains, and the regulation of sewage disposal works. The note provides an overview of the principal legislative regimes, in particular the Urban Waste Water Treatment (England and Wales) Regulations 1994 and the Environmental Permitting (England and Wales) Regulations 2016, and explains how these interact with duties under the Water Industry Act 1991 (WIA 1991) and subsequent amendments. It covers the key concepts underpinning the regime, including agglomerations, collecting systems, treatment requirements and sensitive areas, and addresses system-wide obligations such as monitoring, reporting and the control of storm overflows. More detailed treatment of specific aspects of the regime, including permitting of discharges, operational duties of undertakers, and planning and environmental controls for sewage treatment works, is provided in the following related Practice