A recent retrospective analysis by the Center for Innovation in Regulatory Science (CIRS) compared how long global regulators take to review and approve new active substances (NAS) in their respective jurisdictions between 2015 and 2024. They compared international regulators from the European Medicines Agency (EMA), US Food and Drug Administration (FDA), the Japan Pharmaceuticals and Medical Devices Agency (PMDA), Health Canada, Swissmedic, and the Australian Therapeutic Goods Administration (TGA). Highlight findings from the CIRS report include that Japan's PMDA had the shortest median approval time in 2014, with 290 days and continued to lead, the FDA followed with 356 days, Health Canada with 363 days, TGA with 369 days, EMA with 430 days, and Swissmedic with 444 days. Over half of all new drug applications were filed with the FDA first and it approves the highest number of NAS each year. FDA also topped the list of approvals for products that used the expedited review pathway in 2024, with 59% of products with expedited review getting approved. EMA did not approve any NASs under its accelerated assessment process, which, according to CIRS, was either because they were withdrawn or converted to standard review products. Swissmedic also published a benchmarking study for 2024 comparing its drug approvals with those of EMA and FDA. It found that its drug authorisation times are 'catching up with EMA' with submission and approval gaps between Swissmedic and EMA narrowing. The approval gap between Swissmedic and the FDA also narrowed, although approval times were significantly faster in the US, and the submission gap widened.