This Practice Note, produced in partnership with Osmosis from Elsevier, provides a concise medical overview of respiratory tumours, with a focus on mesothelioma, for personal injury lawyers handling asbestos claims and industrial disease litigation. For further guidance, see: Osmosis from Elsevier video: Mesothelioma—causes, symptoms, diagnosis, treatment & pathology. Generally, what are they? Pathology and causes • uncontrolled division of epithelial cells lining respiratory tract leads to formation of solid tumour • mutated cells become cancerous ◦ resist inhibitory signals, evade immune surveillance • malignant tumours invade basement membrane ◦ carcinoma in situ • metastasis ◦ malignant tumours establish secondary tumours at distant site; lung cancer metastasises quickly ◦ common sites: mediastinum, hilar lymph nodes, lung pleura, breasts, liver, adrenal glands, brain, bones Types Small-cell • small, immature, neuroendocrine cells; divide rapidly, spread quickly Non-small-cell (most common) • large cells; divide, spread slowly ◦ adenocarcinoma (goblet cells) ◦ squamous cell carcinoma (squamous cells) ◦ large cell carcinoma ◦ carcinoid tumours (mature neuroendocrine cells) Nonspecific classification • small-cell carcinoma with poorer prognosis Risk