The European Commission has welcomed a provisional agreement between the European Parliament and the Council of the EU on the sixth revision of the Carcinogens, Mutagens and Reprotoxic Substances Directive (CMRD). The agreement aims to strengthen protection for workers against cancer-causing chemicals by introducing clearer rules and occupational exposure limits for high-risk substances, including cobalt and inorganic cobalt compounds, polycyclic aromatic hydrocarbons (PAHs), 1,4-dioxane and isoprene. To allow industries time to adapt, it includes transitional periods, notably a six-year period with higher limits for cobalt and inorganic cobalt compounds and a temporary exposure limit for PAHs set at twice the new limit for seven years after the Directive enters into force. It also establishes a general occupational exposure limit for isoprene and, for 1,4-dioxane, a general occupational exposure limit, a short-term exposure limit and a biological limit value. In addition, welding fumes will be brought within the scope of the CMRD, new notations on exposure routes will be introduced, and employers’ obligations regarding protective and preventive measures will be clarified, including requirements relating to personal protective equipment and regular breaks for workers who use it. The agreed text now awaits formal adoption by the European Parliament and the Council of the EU.