This Practice Note provides an introduction to chemicals and hazardous substances regulation. It is aimed at trainee solicitors and others who are new to chemicals and hazardous substances regulation and provides information on topics including UK REACH, GB CLP, GB Prior Informed Consent, perfluoroalkyl and polyfluoroalkyl substances (PFAS), pesticides, biocides and persistent organic pollutants (POPs), restriction of hazardous substances (RoHS), asbestos, ozone depleting substances, F-gases, and related health and safety issues. It also includes links to other content with more comprehensive information on these topics. Introduction to chemicals and hazardous substances regulation The regulation of chemicals and hazardous substances is an area of environmental law that is concerned with the risks presented by particular substances to human health and the environment throughout their lifecycle, for example during their manufacture, import, supply, classification, use, storage, transport, and disposal. It is predominantly made up of regulation derived from EU and international laws and the principal regulator is the Health and Safety Executive (HSE). It is interconnected with other areas of environmental law such as waste law, health and safety