This Practice Note provides guidance on the planning regime for nuclear new build in England and Wales. It covers: planning policy, including the Energy National Policy Statements, siting issues, climate change adaptation considerations, addressing nuclear impacts in determining applications, dealing with radioactive waste management, the regime under PA 2008, the Generic Design Assessment process and other consents, Nuclear Sector Deal 2018 and Small Modular Nuclear Reactors (SMRs), judicial review and the implications of Brexit and leaving Euratom.