This Practice Note explains the powers of the Fitness to Practise Committee of the General Pharmaceutical Council (GPhC) to impose sanctions following a fitness to practise hearing. It includes information on the agreement of undertaking, the types of sanctions available to registrants, the purpose of sanctions, general principles of fairness, proportionality and reasonableness, and the Fitness to Practice Committee’s duty to give reasons. This Practice Note also explains the approach taken in relation to cases involving dishonesty and sexual misconduct.