This Practice Note sets out the protection available for trade secrets and confidential information in a commercial context, in particular in cases where technical information is involved. It outlines the law under the Trade Secrets (Enforcement, etc) Regulations 2018, SI 2018/597 and its interplay with common law principles of breach of confidence and gives examples of commercial situations in which disputes might arise. It includes details of the way in which breach of confidence interacts with infringement of intellectual property rights and other causes of action. It considers the definitions of ‘confidential information’, ‘trade secrets’ and ‘know-how’ and how these concepts are dealt with in a commercial context. It reviews the case law relating to secondary liability, common design and knowledge of breach, as well as considering the position regarding subconscious use, derivative use and reverse engineering. The Practice Note contains details of the remedies that are available for breach of confidence, including injunctions, springboard injunctions, damages, account of profits, delivery up and destruction.