This Practice Note outlines how individuals and entities are designated as sanctions targets by the United Nations (UN), UK and EU regimes. It explains what designation are, the legal effects of being designated, and the procedures for listing and de-listing—both at UN level and under the UK’s domestic framework, including under the Sanctions and Anti-Money Laundering Act 2018 (SAMLA 2018), Counter Terrorism Act 2008 (CTA 2008) and Anti-Terrorism, Crime and Security Act 2001 (ACSA 2001). It also explains w EU-level sanctions designations including how EU Member States may propose suggestions as to who should be targeted, with each proposed listing being considered at a closed meeting of Council Member State representatives, in the EU.