This Practice Note sets out some of the UK tax considerations for an innovative business with international or global ambition looking to structure its exploitation of IP. The UK tax treatment of IP-derived profits falling both inside and outside of the UK patent box is considered, as is the possibility of realising such profits outside the UK and the associated CFC risks. The VAT considerations are also briefly outlined. This Practice Note was produced in partnership with Graham Samuel-Gibbon and Michelle Williamson of Taylor Wessing.