A user1 who undertakes a contained use2 involving micro-organisms3 must ensure that the risks to human health and the environment arising from the contained use are reduced to the lowest level that is reasonably practicable4. A user who undertakes a contained use involving larger GMOs5 must ensure that the risks to human health arising from the contained use are reduced to the lowest level that is reasonably practicable6. The measures to be taken in order to comply with the duty in relation to micro-organisms must include the general principles of good microbiological practice and of good occupational safety and hygiene7. For contained use involving larger GMOs, the general principles must be
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