The Department of Health and Social Care has confirmed plans to expand the current Vivaldi study to test thousands more care home staff and residents for their immune response amid the ongoing coronavirus (COVID-19) pandemic. The Vivaldi 2 study, led by University College London (UCL), will more than triple in size to provide a greater understanding of vulnerable groups’ immune response to coronavirus by testing 14,000 care home residents and staff quarterly. Expanding the study will provide a larger and more nationally representative sample of care homes, address important immunity research questions, link immunity data with epidemiological data and offer an opportunity to work with a wider range of small care home chains and independent providers.