European Commission creates list of promising coronavirus (COVID-19) treatments

European Commission creates list of promising coronavirus (COVID-19) treatments

The European Commission has established a portfolio of ten potential coronavirus (COVID-19) therapeutics. The list of therapeutics has been devised through independent scientific advice and focuses on the treatment candidates most likely to be authorised by the European Medicines Agency and made available on the European market. While vaccinations remain the most effective preventative treatment, these therapeutics will be used to treat those who have been infected by the virus and aim to fight infection and alleviate symptoms. A total of 82 therapeutic candidates in late-stage clinical development were analysed by scientific experts, with the ten chosen identified as the ‘most promising for the EU portfolio of COVID-19 treatments’. In coming to their conclusion the different types of products needed for different patient populations and the different stages/severity of the disease were considered.

The ten therapies are divided into three sub-categories as set out below:

• Antiviral monoclonal antibodies that are most efficacious in the earliest stages of infection:

○ Ronapreve, a combination of two monocolonal antibodies casirivimab and imdevimab from Regeneron Pharmaceuticals and Roche

○ Xevudy (sotrovimab) from Vir Biotechnology and GlaxoSmithKline

○ Evusheld, a combination of two monoclonal antibodies tixagevimab and cilgavimab from AstraZeneca

• Oral antivirals for use as quickly as possible after the infection:

○ Molnupiravir from Ridgeback Biotherapeutics and MSD

○ PF-07321332 from Pfizer

○ AT-527 from Atea Pharmaceuticals and Roche

• Immunomodulators to treat hospitalised patients:

○ Actemra (tocilizumab) from Roche Holding

○ Kineret (anakinra) from Swedish Orphan Biovitrum

○ Olumiant (baricitinib) from Eli Lilly

○ Lenzilumab from Humanigen

Alongside its announcement, the Commission has published a Q&A page in which it answers a number of questions regarding the selection process. It is available here.

Source: European Health Union: Commission establishes portfolio of 10 most promising treatments for COVID-19

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